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Interact with the Central Nervous System

2021-09-17 10:30 - 11:30
Microsoft Teams
Istituto IMM di Roma

The understanding of the central nervous system (CNS) behavior is one of the greatest challenges of biomedical research. The CNS operations are based on complex electrochemical interactions between neural cells, influenced by sensory inputs from the external world. To this end, it is critical to implement equipment that can capture highly accurate and detailed information of the CNS state and give the possibility of interacting with it in order to mimic the external world interactions or restore damaged neural functions. This result can be obtained only thanks to a synergetic cooperation among physics, chemists, material scientists, and engineers in the development of new materials, electronics and algorithms. Up to the present, despite several improvements have been implemented in electrode technologies and electronics, the majority of the in vivo experiments are performed in anesthetized or head-fixed awake animals that represent boundary conditions totally different from the real life. To provide long-lasting and reliable behavioral experiments in freely moving animals and possibly develop devices able to cure neurological disorders in humans, different technological aspects should be still improved, namely: implantable electrode stability and durability, their effective integration with wireless communication to avoid cable connections, the use of remote powering in alternative to wired-in implantable batteries, the miniaturization of the system dimensions, develop closed-loop systems and algorithms. These technological issues limit the possibility of biological investigation and the development of more efficient machine-human interfaces. In this seminar, I will give an overview of the main elements of my research activity, I will introduce the CNS structure and its complexity, what means monitor its activity and I will give an overview of the problems that have to be faced in an implant: how the neural system react to the insertion of a foreign body; how it is possible improve the implant recording and stimulation performances by electrode surfaces coating or nano-structuring; how it is possible to monitor neurotransmitters and the difficulty in obtaining a detailed monitoring of them in time and space; and finally, how the improvement in the electronic miniaturization can improve the signal quality and allow less invasive implants and pave the way to implantable closed loop systems. Several steps have been done towards implantable device but we still have a long route ahead. The research in the monitoring and interaction with the CNS has still several challenges to be faced to realize implantable system that can investigate the CNS functions in a more real way and be a less invasive cure for a lot of neural disorders. _________________________ Biography: DR. DAVIDE POLESE is a researcher of the National Research Council of Italy (CNR). He received his master degree in mathematical engineering in 2008 and his PhD degree in engineering of sensorial and learning system on ``Bio-inspired signal processing for chemical sensor array`` in the 2012 both from University of Rome ``Tor Vergata``. During his doctorate, he developed several computational models of the olfactory system to analyze data coming from large array of chemical sensors. He actively participated in European project NEUROChem developing a computational model of the olfactory bulb. In 2013, he joined to Institute for Microelectronics and Microsystems of the National Research Council (CNR-IMM) as post-doctoral researcher. His research activities were focused on the developing of a Wireless Sensor Network (FACTOTHUMS project) and the design of a system for recording and stimulation of the cerebral tissue (Corticonic European project). In the 2015, he has been session chair of the 4th international Sensor Networks conference ``SENSORNETS 2015``. From 2017, he works as permanent researcher at Institute for Microelectronics and Microsystems of the National Research Council. His main research activities are focused on the development of electronic devices


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